Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) targeting human protein-coding genes and encoded in viral vectors have been used to systematically create gene knockouts in a varie...

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Detalhes bibliográficos
Publicado no:G3 (Bethesda)
Main Authors: Hart, Traver, Tong, Amy Hin Yan, Chan, Katie, Van Leeuwen, Jolanda, Seetharaman, Ashwin, Aregger, Michael, Chandrashekhar, Megha, Hustedt, Nicole, Seth, Sahil, Noonan, Avery, Habsid, Andrea, Sizova, Olga, Nedyalkova, Lyudmila, Climie, Ryan, Tworzyanski, Leanne, Lawson, Keith, Sartori, Maria Augusta, Alibeh, Sabriyeh, Tieu, David, Masud, Sanna, Mero, Patricia, Weiss, Alexander, Brown, Kevin R., Usaj, Matej, Billmann, Maximilian, Rahman, Mahfuzur, Costanzo, Michael, Myers, Chad L., Andrews, Brenda J., Boone, Charles, Durocher, Daniel, Moffat, Jason
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2017
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555476/
https://ncbi.nlm.nih.gov/pubmed/28655737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.117.041277
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