Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

The de novo synthesis of fatty acids has emerged as a therapeutic target for various diseases including cancer. Since cancer cells are intrinsically buffered to combat metabolic stress, it is important to understand how cells may adapt to loss of de novo fatty acid biosynthesis. Here we use pooled g...

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Published in:Nat Metab
Main Authors: Aregger, Michael, Lawson, Keith A., Billmann, Maximillian, Costanzo, Michael, Tong, Amy H. Y., Chan, Katherine, Rahman, Mahfuzur, Brown, Kevin R., Ross, Catherine, Usaj, Matej, Nedyalkova, Lucy, Sizova, Olga, Habsid, Andrea, Pawling, Judy, Lin, Zhen-Yuan, Abdouni, Hala, Wong, Cassandra J., Weiss, Alexander, Mero, Patricia, Dennis, James W., Gingras, Anne-Claude, Myers, Chad L., Andrews, Brenda J., Boone, Charles, Moffat, Jason
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566881/
https://ncbi.nlm.nih.gov/pubmed/32694731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-0211-z
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