A method for benchmarking genetic screens reveals a predominant mitochondrial bias

We present FLEX (Functional evaluation of experimental perturbations), a pipeline that leverages several functional annotation resources to establish reference standards for benchmarking human genome‐wide CRISPR screen data and methods for analyzing them. FLEX provides a quantitative measurement of...

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Bibliographic Details
Published in:Mol Syst Biol
Main Authors: Rahman, Mahfuzur, Billmann, Maximilian, Costanzo, Michael, Aregger, Michael, Tong, Amy H Y, Chan, Katherine, Ward, Henry N, Brown, Kevin R, Andrews, Brenda J, Boone, Charles, Moffat, Jason, Myers, Chad L
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138267/
https://ncbi.nlm.nih.gov/pubmed/34018332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.202010013
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