Genome-wide CRISPR knockout screens identify NCAPG as an essential oncogene for hepatocellular carcinoma tumor growth

Hepatocellular carcinoma (HCC) is a common and deadly cancer with limited treatment options. Through genome-wide growth depletion screens using clustered regularly interspaced short palindromic repeats and expression profiling of primary HCC tumors, we identified 13 clinically relevant target genes...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Wang, Yu, Gao, Bin, Tan, Peng Yang, Handoko, Yohana Ayupriyanti, Sekar, Karthik, Deivasigamani, Amudha, Seshachalam, Veerabrahma Pratap, OuYang, Han-Yue, Shi, Ming, Xie, Chan, Goh, Brian Kim Poh, Ooi, London Lucien, Man Hui, Kam
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6662966/
https://ncbi.nlm.nih.gov/pubmed/31022357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802213RR
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