The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

The telomeric protein TRF2 is required to prevent mammalian telomeres from activating DNA damage checkpoints. Here we show that overexpression of TRF2 affects the response of the ATM kinase to DNA damage. Overexpression of TRF2 abrogated the cell cycle arrest after ionizing radiation and diminished...

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Detalhes bibliográficos
Main Authors: Karlseder, Jan, Hoke, Kristina, Mirzoeva, Olga K, Bakkenist, Christopher, Kastan, Michael B, Petrini, John H. J, de Lange, Titia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC509302/
https://ncbi.nlm.nih.gov/pubmed/15314656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020240
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