Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1

The human telomeric DNA binding factor TRF1 (hTRF1) and its interacting proteins TIN2, tankyrase 1 and 2, and PINX1 have been implicated in the regulation of telomerase-dependent telomere length maintenance. Here we show that targeted deletion of exon 1 of the mouse gene encoding Trf1 causes early (...

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Detalhes bibliográficos
Main Authors: Karlseder, Jan, Kachatrian, Leili, Takai, Hiroyuki, Mercer, Kim, Hingorani, Sunil, Jacks, Tyler, de Lange, Titia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193696/
https://ncbi.nlm.nih.gov/pubmed/12944479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.18.6533-6541.2003
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