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Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1
The human telomeric DNA binding factor TRF1 (hTRF1) and its interacting proteins TIN2, tankyrase 1 and 2, and PINX1 have been implicated in the regulation of telomerase-dependent telomere length maintenance. Here we show that targeted deletion of exon 1 of the mouse gene encoding Trf1 causes early (...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC193696/ https://ncbi.nlm.nih.gov/pubmed/12944479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.18.6533-6541.2003 |
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