Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1

The human telomeric DNA binding factor TRF1 (hTRF1) and its interacting proteins TIN2, tankyrase 1 and 2, and PINX1 have been implicated in the regulation of telomerase-dependent telomere length maintenance. Here we show that targeted deletion of exon 1 of the mouse gene encoding Trf1 causes early (...

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Podrobná bibliografie

Vydáno v:	Mol Cell Biol
Hlavní autoři:	Karlseder, Jan, Kachatrian, Leili, Takai, Hiroyuki, Mercer, Kim, Hingorani, Sunil, Jacks, Tyler, de Lange, Titia
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2003
Témata:	Mammalian Genetic Models with Minimal or Complex Phenotypes
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193696/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12944479/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.18.6533-6541.2003
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