Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1

The human telomeric DNA binding factor TRF1 (hTRF1) and its interacting proteins TIN2, tankyrase 1 and 2, and PINX1 have been implicated in the regulation of telomerase-dependent telomere length maintenance. Here we show that targeted deletion of exon 1 of the mouse gene encoding Trf1 causes early (...

Description complète

Détails bibliographiques

Publié dans:	Mol Cell Biol
Auteurs principaux:	Karlseder, Jan, Kachatrian, Leili, Takai, Hiroyuki, Mercer, Kim, Hingorani, Sunil, Jacks, Tyler, de Lange, Titia
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 2003
Sujets:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193696/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12944479/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.18.6533-6541.2003
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!