Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1
The human telomeric DNA binding factor TRF1 (hTRF1) and its interacting proteins TIN2, tankyrase 1 and 2, and PINX1 have been implicated in the regulation of telomerase-dependent telomere length maintenance. Here we show that targeted deletion of exon 1 of the mouse gene encoding Trf1 causes early (...
Gorde:
| Argitaratua izan da: | Mol Cell Biol |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Taylor & Francis
2003
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC193696/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12944479/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.18.6533-6541.2003 |
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