Targeting Assay To Study the cis Functions of Human Telomeric Proteins: Evidence for Inhibition of Telomerase by TRF1 and for Activation of Telomere Degradation by TRF2

We investigated the control of telomere length by the human telomeric proteins TRF1 and TRF2. To this end, we established telomerase-positive cell lines in which the targeting of these telomeric proteins to specific telomeres could be induced. We demonstrate that their targeting leads to telomere sh...

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Detalhes bibliográficos
Main Authors: Ancelin, Katia, Brunori, Michele, Bauwens, Serge, Koering, Catherine-Elaine, Brun, Christine, Ricoul, Michelle, Pommier, Jean-Patrick, Sabatier, Laure, Gilson, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133804/
https://ncbi.nlm.nih.gov/pubmed/11971978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.10.3474-3487.2002
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