The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

The telomeric protein TRF2 is required to prevent mammalian telomeres from activating DNA damage checkpoints. Here we show that overexpression of TRF2 affects the response of the ATM kinase to DNA damage. Overexpression of TRF2 abrogated the cell cycle arrest after ionizing radiation and diminished...

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Autores principales: Karlseder, Jan, Hoke, Kristina, Mirzoeva, Olga K, Bakkenist, Christopher, Kastan, Michael B, Petrini, John H. J, de Lange, Titia
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2004
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC509302/
https://ncbi.nlm.nih.gov/pubmed/15314656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020240
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