The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

The telomeric protein TRF2 is required to prevent mammalian telomeres from activating DNA damage checkpoints. Here we show that overexpression of TRF2 affects the response of the ATM kinase to DNA damage. Overexpression of TRF2 abrogated the cell cycle arrest after ionizing radiation and diminished...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Karlseder, Jan, Hoke, Kristina, Mirzoeva, Olga K, Bakkenist, Christopher, Kastan, Michael B, Petrini, John H. J, de Lange, Titia
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2004
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC509302/
https://ncbi.nlm.nih.gov/pubmed/15314656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020240
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