The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

The telomeric protein TRF2 is required to prevent mammalian telomeres from activating DNA damage checkpoints. Here we show that overexpression of TRF2 affects the response of the ATM kinase to DNA damage. Overexpression of TRF2 abrogated the cell cycle arrest after ionizing radiation and diminished...

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Autors principals: Karlseder, Jan, Hoke, Kristina, Mirzoeva, Olga K, Bakkenist, Christopher, Kastan, Michael B, Petrini, John H. J, de Lange, Titia
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2004
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC509302/
https://ncbi.nlm.nih.gov/pubmed/15314656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020240
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