Proteolytic maturation of α(2)δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels

The auxiliary α(2)δ subunits of voltage-gated calcium channels are extracellular membrane-associated proteins, which are post-translationally cleaved into disulfide-linked polypeptides α(2) and δ. We now show, using α(2)δ constructs containing artificial cleavage sites, that this processing is an es...

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Udgivet i:eLife
Main Authors: Kadurin, Ivan, Ferron, Laurent, Rothwell, Simon W, Meyer, James O, Douglas, Leon R, Bauer, Claudia S, Lana, Beatrice, Margas, Wojciech, Alexopoulos, Orpheas, Nieto-Rostro, Manuela, Pratt, Wendy S, Dolphin, Annette C
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Biochemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5092059/
https://ncbi.nlm.nih.gov/pubmed/27782881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21143
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