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Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α(2)δ-1-subunit but does not interact with α(2)δ-1 on the cell-surface when co-expressed
The α(2)δ proteins are auxiliary subunits of voltage-gated calcium channels, and influence their trafficking and biophysical properties. The α(2)δ ligand gabapentin interacts with α(2)δ-1, and inhibits calcium channel trafficking. However, α(2)-1 has also been proposed to play a synaptogenic role, i...
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| Published in: | Sci Rep |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4830977/ https://ncbi.nlm.nih.gov/pubmed/27076051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24531 |
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