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Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α(2)δ-1-subunit but does not interact with α(2)δ-1 on the cell-surface when co-expressed

The α(2)δ proteins are auxiliary subunits of voltage-gated calcium channels, and influence their trafficking and biophysical properties. The α(2)δ ligand gabapentin interacts with α(2)δ-1, and inhibits calcium channel trafficking. However, α(2)-1 has also been proposed to play a synaptogenic role, i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lana, Beatrice, Page, Karen M., Kadurin, Ivan, Ho, Shuxian, Nieto-Rostro, Manuela, Dolphin, Annette C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830977/
https://ncbi.nlm.nih.gov/pubmed/27076051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24531
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