Differential upregulation in DRG neurons of an α(2)δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury

The α(2)δ-1 protein is an auxiliary subunit of voltage-gated calcium channels, critical for neurotransmitter release. It is upregulated in dorsal root ganglion (DRG) neurons following sensory nerve injury, and is also the therapeutic target of the gabapentinoid drugs, which are efficacious in both e...

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Hauptverfasser: Lana, Beatrice, Schlick, Bettina, Martin, Stuart, Pratt, Wendy S., Page, Karen M., Goncalves, Leonor, Rahman, Wahida, Dickenson, Anthony H., Bauer, Claudia S., Dolphin, Annette C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lippincott Williams & Wilkins 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988960/
https://ncbi.nlm.nih.gov/pubmed/24315988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.12.001
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