Pharmacological disruption of calcium channel trafficking by the α(2)δ ligand gabapentin

The mechanism of action of the antiepileptic and antinociceptive drugs of the gabapentinoid family has remained poorly understood. Gabapentin (GBP) binds to an exofacial epitope of the α(2)δ-1 and α(2)δ-2 auxiliary subunits of voltage-gated calcium channels, but acute inhibition of calcium currents...

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Detalhes bibliográficos
Main Authors: Hendrich, Jan, Van Minh, Alexandra Tran, Heblich, Fay, Nieto-Rostro, Manuela, Watschinger, Katrin, Striessnig, Jörg, Wratten, Jack, Davies, Anthony, Dolphin, Annette C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265195/
https://ncbi.nlm.nih.gov/pubmed/18299583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708930105
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