Pharmacological disruption of calcium channel trafficking by the α(2)δ ligand gabapentin

Eitemau Tebyg

• The α(2)δ Ligand Gabapentin Inhibits the Rab11-Dependent Recycling of the Calcium Channel Subunit α(2)δ-2
  gan: Tran-Van-Minh, Alexandra, et al.
  Cyhoeddwyd: (2010)
• The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of α(2)δ subunits is key to trafficking voltage-gated Ca(2)+ channels
  gan: Cantí, C., et al.
  Cyhoeddwyd: (2005)
• Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo
  gan: Nieto-Rostro, Manuela, et al.
  Cyhoeddwyd: (2018)
• LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α(2)δ-1 subunit
  gan: Kadurin, Ivan, et al.
  Cyhoeddwyd: (2017)
• Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α(2)δ-1-subunit but does not interact with α(2)δ-1 on the cell-surface when co-expressed
  gan: Lana, Beatrice, et al.
  Cyhoeddwyd: (2016)