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Pharmacological disruption of calcium channel trafficking by the α(2)δ ligand gabapentin
The mechanism of action of the antiepileptic and antinociceptive drugs of the gabapentinoid family has remained poorly understood. Gabapentin (GBP) binds to an exofacial epitope of the α(2)δ-1 and α(2)δ-2 auxiliary subunits of voltage-gated calcium channels, but acute inhibition of calcium currents...
Gorde:
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265195/ https://ncbi.nlm.nih.gov/pubmed/18299583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708930105 |
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