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Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo
The auxiliary α(2)δ calcium channel subunits play key roles in voltage-gated calcium channel function. Independent of this, α(2)δ-1 has also been suggested to be important for synaptogenesis. Using an epitope-tagged knockin mouse strategy, we examined the effect of α(2)δ-1 on Ca(V)2.2 localization i...
Gorde:
| Argitaratua izan da: | Proc Natl Acad Sci U S A |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6305000/ https://ncbi.nlm.nih.gov/pubmed/30487217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811212115 |
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