Ablation of α(2)δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo

The auxiliary α(2)δ calcium channel subunits play key roles in voltage-gated calcium channel function. Independent of this, α(2)δ-1 has also been suggested to be important for synaptogenesis. Using an epitope-tagged knockin mouse strategy, we examined the effect of α(2)δ-1 on Ca(V)2.2 localization i...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Nieto-Rostro, Manuela, Ramgoolam, Krishma, Pratt, Wendy S., Kulik, Akos, Dolphin, Annette C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305000/
https://ncbi.nlm.nih.gov/pubmed/30487217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1811212115
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