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Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.
Apo E is a key molecule in the lipoprotein metabolism; thus, genetic manipulation of apo E may prove useful in the treatment of hypercholesterolemia. To test the feasibility of this idea, we have generated low density lipoprotein receptor (LDLR) knockout mice that overexpress the rat apo E transgene...
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Hauptverfasser: | , , , , , , , , , |
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Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
1998
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Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC508897/ https://ncbi.nlm.nih.gov/pubmed/9664080 |
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