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Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.
Apo E is a key molecule in the lipoprotein metabolism; thus, genetic manipulation of apo E may prove useful in the treatment of hypercholesterolemia. To test the feasibility of this idea, we have generated low density lipoprotein receptor (LDLR) knockout mice that overexpress the rat apo E transgene...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508897/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9664080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1124 |
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