Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.

Apo E is a key molecule in the lipoprotein metabolism; thus, genetic manipulation of apo E may prove useful in the treatment of hypercholesterolemia. To test the feasibility of this idea, we have generated low density lipoprotein receptor (LDLR) knockout mice that overexpress the rat apo E transgene...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Osuga, J, Yonemoto, M, Yamada, N, Shimano, H, Yagyu, H, Ohashi, K, Harada, K, Kamei, T, Yazaki, Y, Ishibashi, S
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1998
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508897/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9664080/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1124
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