Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.

Apo E is a key molecule in the lipoprotein metabolism; thus, genetic manipulation of apo E may prove useful in the treatment of hypercholesterolemia. To test the feasibility of this idea, we have generated low density lipoprotein receptor (LDLR) knockout mice that overexpress the rat apo E transgene...

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Dades bibliogràfiques

Publicat a:	J Clin Invest
Autors principals:	Osuga, J, Yonemoto, M, Yamada, N, Shimano, H, Yagyu, H, Ohashi, K, Harada, K, Kamei, T, Yazaki, Y, Ishibashi, S
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical Investigation 1998
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508897/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9664080/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1124
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