Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.

Apolipoprotein E (apoE) has a high affinity to cell-surface low density lipoprotein (LDL) receptor. To determine the role of apoE in plasma lipoprotein metabolism, transgenic mouse lines with integrated rat apoE gene under the control of the metallothionein promoter were established. We found that a...

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Hauptverfasser: Shimano, H, Yamada, N, Katsuki, M, Shimada, M, Gotoda, T, Harada, K, Murase, T, Fukazawa, C, Takaku, F, Yazaki, Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC48530/
https://ncbi.nlm.nih.gov/pubmed/1542669
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