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Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center
The first broad-spectrum antibiotic chloramphenicol and one of the newest clinically important antibacterials, linezolid, inhibit protein synthesis by targeting the peptidyl transferase center of the bacterial ribosome. Because antibiotic binding should prevent the placement of aminoacyl-tRNA in the...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5086994/ https://ncbi.nlm.nih.gov/pubmed/27791002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613055113 |
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