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Binding of macrolide antibiotics leads to ribosomal selection against specific substrates based on their charge and size
Macrolide antibiotic binding to the ribosome inhibits catalysis of peptide bond formation between specific donor and acceptor substrates. Why particular reactions are problematic for the macrolide-bound ribosome remains unclear. Using comprehensive mutational analysis and biochemical experiments wit...
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| Pubblicato in: | Cell Rep |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5118941/ https://ncbi.nlm.nih.gov/pubmed/27498876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.018 |
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