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How macrolide antibiotics work
Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been viewed as ‘tunnel plugs’ that stop synthesis of every protein. More recent evidence, however, demonstrates that macro...
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| Published in: | Trends Biochem Sci |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6108949/ https://ncbi.nlm.nih.gov/pubmed/30054232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2018.06.011 |
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