A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria

While most of the ribosome-targeting antibiotics are bacteriostatic, some members of the macrolide class demonstrate considerable bactericidal activity. We previously showed that an extended alkyl-aryl side chain is the key structural element determining the macrolides’ slow dissociation from the ri...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Svetlov, Maxim S., Cohen, Sophie, Alsuhebany, Nada, Vázquez-Laslop, Nora, Mankin, Alexander S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995004/
https://ncbi.nlm.nih.gov/pubmed/31932436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918948117
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