Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center

The first broad-spectrum antibiotic chloramphenicol and one of the newest clinically important antibacterials, linezolid, inhibit protein synthesis by targeting the peptidyl transferase center of the bacterial ribosome. Because antibiotic binding should prevent the placement of aminoacyl-tRNA in the...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Marks, James, Kannan, Krishna, Roncase, Emily J., Klepacki, Dorota, Kefi, Amira, Orelle, Cédric, Vázquez-Laslop, Nora, Mankin, Alexander S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086994/
https://ncbi.nlm.nih.gov/pubmed/27791002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613055113
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