Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center

The first broad-spectrum antibiotic chloramphenicol and one of the newest clinically important antibacterials, linezolid, inhibit protein synthesis by targeting the peptidyl transferase center of the bacterial ribosome. Because antibiotic binding should prevent the placement of aminoacyl-tRNA in the...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Marks, James, Kannan, Krishna, Roncase, Emily J., Klepacki, Dorota, Kefi, Amira, Orelle, Cédric, Vázquez-Laslop, Nora, Mankin, Alexander S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086994/
https://ncbi.nlm.nih.gov/pubmed/27791002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613055113
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