Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

Current drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently reported that the 4-aminoquinoline derivative huprine Y, d...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Bioorg Med Chem
Egile Nagusiak: Sola, Irene, Artigas, Albert, Taylor, Martin C., Pérez-Areales, F. Javier, Viayna, Elisabet, Clos, M. Victòria, Pérez, Belén, Wright, Colin W., Kelly, John M., Muñoz-Torrero, Diego
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier Science 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080452/
https://ncbi.nlm.nih.gov/pubmed/27591008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.036
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