Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

Current drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently reported that the 4-aminoquinoline derivative huprine Y, d...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Sola, Irene, Artigas, Albert, Taylor, Martin C., Pérez-Areales, F. Javier, Viayna, Elisabet, Clos, M. Victòria, Pérez, Belén, Wright, Colin W., Kelly, John M., Muñoz-Torrero, Diego
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080452/
https://ncbi.nlm.nih.gov/pubmed/27591008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.036
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