Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

Current drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently reported that the 4-aminoquinoline derivative huprine Y, d...

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Published in:Bioorg Med Chem
Main Authors: Sola, Irene, Artigas, Albert, Taylor, Martin C., Pérez-Areales, F. Javier, Viayna, Elisabet, Clos, M. Victòria, Pérez, Belén, Wright, Colin W., Kelly, John M., Muñoz-Torrero, Diego
Format: Artigo
Language:Inglês
Published: Elsevier Science 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080452/
https://ncbi.nlm.nih.gov/pubmed/27591008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.036
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