Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents

Current drugs against human African trypanosomiasis (HAT) suffer from several serious drawbacks. The search for novel, effective, brain permeable, safe, and inexpensive antitrypanosomal compounds is therefore an urgent need. We have recently reported that the 4-aminoquinoline derivative huprine Y, d...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Sola, Irene, Artigas, Albert, Taylor, Martin C., Pérez-Areales, F. Javier, Viayna, Elisabet, Clos, M. Victòria, Pérez, Belén, Wright, Colin W., Kelly, John M., Muñoz-Torrero, Diego
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080452/
https://ncbi.nlm.nih.gov/pubmed/27591008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.036
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