Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.

Proteolytic degradation of aggrecan is a hallmark of the pathology of arthritis, yet the identity of the enzyme(s) in cartilage responsible for this degradation is unknown. Previous studies have suggested that the matrix metalloproteinases (MMPs) may be involved but there has been no definitive evid...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Fosang, A J, Last, K, Maciewicz, R A
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1996
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507679/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8941646/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119040
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