Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and quantity of MMP-generated aggrecan G1 fragments terminating in V...

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Опубликовано в: :J Clin Invest
Главные авторы: Lark, M W, Bayne, E K, Flanagan, J, Harper, C F, Hoerrner, L A, Hutchinson, N I, Singer, I I, Donatelli, S A, Weidner, J R, Williams, H R, Mumford, R A, Lohmander, L S
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 1997
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508169/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9202061/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119526
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