Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

Aggrecan loss from cartilage in arthritis is mediated by aggrecanases. Aggrecanases cleave aggrecan preferentially in the chondroitin sulfate–2 (CS-2) domain and secondarily at the E(373)↓(374)A bond in the interglobular domain (IGD). However, IGD cleavage may be more deleterious for cartilage biome...

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Detalhes bibliográficos
Principais autores: Little, Christopher B., Meeker, Clare T., Golub, Suzanne B., Lawlor, Kate E., Farmer, Pamela J., Smith, Susan M., Fosang, Amanda J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866253/
https://ncbi.nlm.nih.gov/pubmed/17510707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30765
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