Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

Aggrecan loss from cartilage in arthritis is mediated by aggrecanases. Aggrecanases cleave aggrecan preferentially in the chondroitin sulfate–2 (CS-2) domain and secondarily at the E(373)↓(374)A bond in the interglobular domain (IGD). However, IGD cleavage may be more deleterious for cartilage biome...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Little, Christopher B., Meeker, Clare T., Golub, Suzanne B., Lawlor, Kate E., Farmer, Pamela J., Smith, Susan M., Fosang, Amanda J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866253/
https://ncbi.nlm.nih.gov/pubmed/17510707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30765
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge