Загрузка...

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

Aggrecan loss from cartilage in arthritis is mediated by aggrecanases. Aggrecanases cleave aggrecan preferentially in the chondroitin sulfate–2 (CS-2) domain and secondarily at the E(373)↓(374)A bond in the interglobular domain (IGD). However, IGD cleavage may be more deleterious for cartilage biome...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Little, Christopher B., Meeker, Clare T., Golub, Suzanne B., Lawlor, Kate E., Farmer, Pamela J., Smith, Susan M., Fosang, Amanda J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2007
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866253/
https://ncbi.nlm.nih.gov/pubmed/17510707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30765
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!