Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.

Native and recombinant neutrophil collagenase (MMP-8) was shown to cleave at the E373-A374 'aggrecanase' site in the interglobular domain of aggrecan. The time course of digestion in vitro showed that MMP-8 cleaved initially at N341-F342, the predominant metalloproteinase site, before clea...

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Autores principales: Fosang, A J, Last, K, Neame, P J, Murphy, G, Knäuper, V, Tschesche, H, Hughes, C E, Caterson, B, Hardingham, T E
Formato: Artigo
Lenguaje:Inglês
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1137499/
https://ncbi.nlm.nih.gov/pubmed/7998967
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