Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.

Míreanna Comhchosúla

• Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.
  le: Fosang, A J, et al.
  Foilsithe: (1993)
• Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
  le: Büttner, F H, et al.
  Foilsithe: (1998)
• Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
  le: Little, Christopher B., et al.
  Foilsithe: (2007)
• Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
  le: Little, Christopher B., et al.
  Foilsithe: (2008)
• The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.
  le: Sandy, J D, et al.
  Foilsithe: (1992)