Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.

Lignende værker

• Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
  af: Lark, M W, et al.
  Udgivet: (1997)
• The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.
  af: Stanton, Heather, et al.
  Udgivet: (2002)
• Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity
  af: Karsdal, Morten A, et al.
  Udgivet: (2008)
• Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
  af: Little, C B, et al.
  Udgivet: (1999)
• Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
  af: Hughes, C E, et al.
  Udgivet: (1995)