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The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.

Fragments of fibronectin occur naturally in vivo and are increased in the synovial fluid of arthritis patients. We have studied the 45 kDa fragment (Fn-f 45), representing the N-terminal collagen-binding domain of fibronectin, for its ability to modulate the expression of metalloproteinases by porci...

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Autori principali: Stanton, Heather, Ung, Linh, Fosang, Amanda J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222560/
https://ncbi.nlm.nih.gov/pubmed/11988091
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