Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.

Ítems similars

• Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
  per: Little, C B, et al.
  Publicat: (1999)
• Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope.
  per: Mort, J S, et al.
  Publicat: (1998)
• Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
  per: Fosang, A J, et al.
  Publicat: (1996)
• Variations in aggrecan structure modulate its susceptibility to aggrecanases.
  per: Roughley, Peter J, et al.
  Publicat: (2003)
• The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.
  per: Stanton, Heather, et al.
  Publicat: (2002)