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Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target LC domain polymers

Two complementary approaches were used in search of the intracellular targets of the toxic PR poly-dipeptide encoded by the repeat sequences expanded in the C9orf72 form of amyotrophic lateral sclerosis. The top categories of PR(n)-bound proteins include constituents of non-membrane invested cellula...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell
Prif Awduron: Lin, Yi, Mori, Eiichiro, Kato, Masato, Xiang, Siheng, Wu, Leeju, Kwon, Ilmin, McKnight, Steven L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076566/
https://ncbi.nlm.nih.gov/pubmed/27768897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.10.003
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