Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model

Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age influences the role of MMP8 in sepsis. First, we compared s...

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Bibliografski detalji
Izdano u:Mol Med
Glavni autori: Atkinson, Sarah J, Varisco, Brian M, Sandquist, Mary, Daly, Meghan N, Klingbeil, Lindsey, Kuethe, Joshua W, Midura, Emily F, Harmon, Kelli, Opoka, Amy, Lahni, Patrick, Piraino, Giovanna, Hake, Paul, Zingarelli, Basilia, Mortensen, Joel E, Wynn, James L, Wong, Hector R
Format: Artigo
Jezik:Inglês
Izdano: Feinstein Institute for Medical Research 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072408/
https://ncbi.nlm.nih.gov/pubmed/27506554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00058
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