Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model

Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 (MMP8) improves survival in an adult murine sepsis model. Because developmental age influences the host inflammatory response, we hypothesized that developmental age influences the role of MMP8 in sepsis. First, we compared s...

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Vydáno v:Mol Med
Hlavní autoři: Atkinson, Sarah J, Varisco, Brian M, Sandquist, Mary, Daly, Meghan N, Klingbeil, Lindsey, Kuethe, Joshua W, Midura, Emily F, Harmon, Kelli, Opoka, Amy, Lahni, Patrick, Piraino, Giovanna, Hake, Paul, Zingarelli, Basilia, Mortensen, Joel E, Wynn, James L, Wong, Hector R
Médium: Artigo
Jazyk:Inglês
Vydáno: Feinstein Institute for Medical Research 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072408/
https://ncbi.nlm.nih.gov/pubmed/27506554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00058
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