INTESTINE-DERIVED MATRIX METALLOPROTEINASE-8 IS A CRITICAL MEDIATOR OF POLYMICROBIAL PERITONITIS

OBJECTIVE: Inhibition of matrix metalloproteinase-8 (MMP8) improves survival following cecal ligation and puncture (CLP) in mice, making it a potential therapeutic target. In the current study we expand our understanding of the role of MMP8 in sepsis by employing an adoptive transfer approach and al...

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發表在:Crit Care Med
Main Authors: Atkinson, Sarah J., Nolan, Meghan, Klingbeil, Lindsey, Harmon, Kelli, Lahni, Patrick, Zingarelli, Basilia, Wong, Hector R.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792672/
https://ncbi.nlm.nih.gov/pubmed/26496446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000001374
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