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Metformin exerts beneficial effects in hemorrhagic shock in an AMPKα1-independent manner
Despite therapeutic advances in hemorrhagic shock, mortality from multiple organ failure remains high. AMP-activated protein kinase (AMPK) is involved in cellular energy homeostasis. Two catalytic subunits, α1 and α2, have been identified, with α1 subunit largely expressed in major organs. Here, we...
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| Publicado no: | Shock |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5809284/ https://ncbi.nlm.nih.gov/pubmed/28915221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000984 |
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