Metformin exerts beneficial effects in hemorrhagic shock in an AMPKα1-independent manner

Despite therapeutic advances in hemorrhagic shock, mortality from multiple organ failure remains high. AMP-activated protein kinase (AMPK) is involved in cellular energy homeostasis. Two catalytic subunits, α1 and α2, have been identified, with α1 subunit largely expressed in major organs. Here, we...

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Vydáno v:Shock
Hlavní autoři: Kim, Paul, Piraino, Giovanna, O’Connor, Michael, Hake, Paul W., Wolfe, Vivian, Lahni, Patrick, Zingarelli, Basilia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809284/
https://ncbi.nlm.nih.gov/pubmed/28915221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000984
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