Hepatocyte-Specific Deletion of AMPKα1 Results in Worse Outcomes in Mice Subjected to Sepsis in a Sex-Specific Manner

Alterations in the energy homeostasis contribute to sepsis-mediated multiple organ failure. The liver plays a central role in metabolism and participates to the innate immune and inflammatory responses of sepsis. Several clinical and experimental studies have suggested that females are less suscepti...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Kikuchi, Satoshi, Piraino, Giovanna, O'Connor, Michael, Wolfe, Vivian, Ridings, Kiana, Lahni, Patrick, Zingarelli, Basilia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031478/
https://ncbi.nlm.nih.gov/pubmed/32117320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00210
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