Autophagy and mitochondrial biogenesis impairment contribute to age-dependent liver injury in experimental sepsis: dysregulation of AMP-activated protein kinase pathway

Age is an independent risk factor of multiple organ failure in patients with sepsis. However, the age-related mechanisms of injury are not known. AMPK is a crucial regulator of energy homeostasis, which controls mitochondrial biogenesis by activation of peroxisome proliferator-activated receptor-γ c...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Inata, Yu, Kikuchi, Satoshi, Samraj, Ravi S., Hake, Paul W., O’Connor, Michael, Ledford, John R., O’Connor, James, Lahni, Patrick, Wolfe, Vivian, Piraino, Giovanna, Zingarelli, Basilia
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888394/
https://ncbi.nlm.nih.gov/pubmed/28974562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700576R
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