Deglycosylated Anti-Aβ Antibody Dose–Response Effects on Pathology and Memory in APP Transgenic Mice

Anti-Aβ antibody administration to amyloid-depositing transgenic mice can reverse amyloid pathology and restore memory function. However, in old mice, these treatments also increase vascular leakage and promote formation of vascular amyloid deposits. Deglycosylated antibodies with reduced affinity f...

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Publicado en:J Neuroimmune Pharmacol
Autores principales: Karlnoski, Rachel A., Rosenthal, Arnon, Alamed, Jennifer, Ronan, Victoria, Gordon, Marcia N., Gottschall, Paul E., Grimm, Jan, Pons, Jaume, Morgan, Dave
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072283/
https://ncbi.nlm.nih.gov/pubmed/18607758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-008-9114-6
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