Up-Regulation of Bcl-2 in APP Transgenic Mice is Associated with Neuroprotection

Aβ-induced neurodegeneration is limited in APP and APP+PS1 transgenic mice. In middle-aged APP+PS1 transgenic mice, we found significantly increased Bcl-2 expression. The increase in Bcl-2 is restricted to amyloid-containing brain regions and is not found at young ages, suggesting that Aβ deposition...

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Detalhes bibliográficos
Main Authors: Karlnoski, Rachel, Wilcock, Donna, Dickey, Chad, Ronan, Victoria, Gordon, Marcia N., Zhang, Wenru, Morgan, Dave, Taglialatela, Giulio
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885419/
https://ncbi.nlm.nih.gov/pubmed/17067805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2006.09.007
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