Deglycosylated Anti-Aβ Antibody Dose–Response Effects on Pathology and Memory in APP Transgenic Mice

Anti-Aβ antibody administration to amyloid-depositing transgenic mice can reverse amyloid pathology and restore memory function. However, in old mice, these treatments also increase vascular leakage and promote formation of vascular amyloid deposits. Deglycosylated antibodies with reduced affinity f...

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Detalhes bibliográficos
Publicado no:J Neuroimmune Pharmacol
Main Authors: Karlnoski, Rachel A., Rosenthal, Arnon, Alamed, Jennifer, Ronan, Victoria, Gordon, Marcia N., Gottschall, Paul E., Grimm, Jan, Pons, Jaume, Morgan, Dave
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072283/
https://ncbi.nlm.nih.gov/pubmed/18607758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-008-9114-6
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