Deglycosylated Anti-Amyloid-β Antibodies Eliminate Cognitive Deficits and Reduce Parenchymal Amyloid with Minimal Vascular Consequences in Aged Amyloid Precursor Protein Transgenic Mice

Systemic administration of anti-amyloid-β (Aβ) antibodies results in reduced parenchymal amyloid but increased vascular amyloid and microhemorrhage in amyloid precursor protein (APP) transgenic mice. Here, we evaluate the effects of reducing effector interactions of the antibody via deglycosylation....

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Publicado no:J Neurosci
Main Authors: Wilcock, Donna M., Alamed, Jennifer, Gottschall, Paul E., Grimm, Jan, Rosenthal, Arnon, Pons, Jaume, Ronan, Victoria, Symmonds, Keisha, Gordon, Marcia N., Morgan, Dave
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675288/
https://ncbi.nlm.nih.gov/pubmed/16707786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0695-06.2006
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