Deglycosylated Anti-Amyloid-β Antibodies Eliminate Cognitive Deficits and Reduce Parenchymal Amyloid with Minimal Vascular Consequences in Aged Amyloid Precursor Protein Transgenic Mice

Systemic administration of anti-amyloid-β (Aβ) antibodies results in reduced parenchymal amyloid but increased vascular amyloid and microhemorrhage in amyloid precursor protein (APP) transgenic mice. Here, we evaluate the effects of reducing effector interactions of the antibody via deglycosylation....

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Publié dans:J Neurosci
Auteurs principaux: Wilcock, Donna M., Alamed, Jennifer, Gottschall, Paul E., Grimm, Jan, Rosenthal, Arnon, Pons, Jaume, Ronan, Victoria, Symmonds, Keisha, Gordon, Marcia N., Morgan, Dave
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2006
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675288/
https://ncbi.nlm.nih.gov/pubmed/16707786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0695-06.2006
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